Buprenorphine Used With Treatment Resistant Depression in Older Adults
Status:
Completed
Trial end date:
2018-04-30
Target enrollment:
Participant gender:
Summary
The investigators are conducting a research study to learn about the safety and benefit of
using a medication called buprenorphine for patients with difficult to treat depression. This
research study is testing whether combining two medications will be effective in treating
depression when initial treatment with just one antidepressant does not relieve the
depressive symptoms; this is what is called "difficult to treat depression" or "treatment
resistant depression". The two medications the investigators are using are: an
anti-depressant medication called venlafaxine extended release (venlafaxine XR), which is the
generic form of Effexor, and buprenorphine. Buprenorphine is a medication that is FDA
approved for the treatment of opioid dependence. The investigators are testing whether adding
buprenorphine to venlafaxine XR enhances treatment response.