The purpose of this study is to determine if the opioid agonist effects of doses of 4/1 mg,
8/2 mg, and 16/4 mg of buprenorphine/naloxone can be completely blocked by 50 mg of oral
naltrexone. This study will provide data to support the design of a similar study of the
depot formulation of naltrexone and ultimately to study this combination for the treatment of
cocaine dependence.
Phase:
Phase 1
Details
Lead Sponsor:
National Institute on Drug Abuse (NIDA)
Treatments:
Buprenorphine Buprenorphine, Naloxone Drug Combination Naloxone Naltrexone