Buprenorphine Dose Escalation Trial for Treatment of Non-Dependent Opiate Users - 2
Status:
Completed
Trial end date:
1998-07-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to evaluate the effect, pharmacokinetics and dose
proportionality of buprenorphine when administered to non-dependent opiate users. 1) To
evaluate whether plasma concentrations of buprenorphine increase proportionally to
buprenorphine dose. 2) To evaluate the dose-response of subjective and physiological effects
of buprenorphine; and 3) To determine the safety of buprenorphine.