Buprenorphine Disposition and Cyclosporine

• Status: Completed
• Trial end date: 2016-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The determine the effect of cyclosporine on buprenorphine disposition

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Washington University School of Medicine
• Treatments: Buprenorphine; Cyclosporine; Cyclosporins

Criteria

Inclusion Criteria:

• 18-50 yr old

• Good general health with no remarkable medical conditions

• BMI < 33

• Provide informed consent

Exclusion Criteria:

• Known history of liver or kidney disease

• Use of prescription or non prescription medications, herbals or foods known to be metabolized by or affecting CYP3A

• Females who are pregnant or nursing

• Known history of drug or alcohol addiction (prior or present addiction or treatment for addiction)

• Direct physical access to and routine handling of addicting drugs in the regular course of duty (a routine exclusion from studies of drugs with addiction potential)