Bupivacaine Versus Lidocaine Infiltration for Postoperative Pain in Thyroid Surgery

• Status: Not yet recruiting
• Trial end date: 2024-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare the efficacy of Bupivicaine and Lidocaine for postoperative pain control in thyroid surgery.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: St. Joseph's Healthcare Hamilton
• Treatments: Bupivacaine; Epinephrine; Epinephryl borate; Lidocaine; Racepinephrine

Criteria

Inclusion Criteria:

• Diagnosis of thyroid disease (malignant tumors T1-T3/NX-N1a, benign tumors)

• Planned for thyroid surgery with midline neck incision (total thyroidectomy, completion thyroidectomy, with or without central neck dissection)

• Will be admitted for at least 12h postoperatively

Exclusion Criteria:

• Thyroid cancer staged as T4 (invasion, anaplastic) or requiring sternotomy

• Thyroid cancer staged as N1b (cervical, retropharyngeal, superior mediastinal nodal involvement)

• Previous ipsilateral thyroid surgery to operation side

• Previous total thyroidectomy or completion thyroidectomy

• History of neck radiation therapy

• Neck dissection beyond central neck (levels 1-5)

• Goiter extending beyond sternal notch (intrathoracic) or requiring sternotomy

• Surgery requiring extension of incision beyond 8 cm

• History of diabetes mellitus

• History of renal or liver disease

• History of narcotic abuse

• History of chronic pain medications use in past 6 months for any condition

• History of coagulation defect

• Allergy to Bupivacaine or Lidocaine