Overview

Brown Adipose Tissue Metabolism in Type 2 Diabetes

Status:
Recruiting
Trial end date:
2023-12-01
Target enrollment:
0
Participant gender:
All
Summary
Activation of brown adipose tissue (BAT) by cold exposure. BAT thermogenesis and BAT volume of metabolic activity will be assessed by Positron-Emitting-Tomography (PET/CT) and MRI/MRS imaging and new pharmacological methods to modulate BAT thermogenesis. All previous data on the functioning of Brown Adipose Tissue (BAT) were obtained by Positron-Emitting-Tomography (PET) imaging studies using fluorodeoxyglucose F18 ( [18F]- FDG). This approach underestimates the actual activity of the BAT. In this study, the investigator is going to use a new PET tracer (C11-palmitate) which is a fat molecule. This will allow to quantify more accurately the activity of brown fat.
Phase:
N/A
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Université de Sherbrooke
Treatments:
Niacin
Niacinamide
Nicotinic Acids
Criteria
Inclusion Criteria:

- 10 men and 10 women with T2D.

- 10 non-diabetic men and 10 non-diabetic women (matched for sex, BMI and age to the T2D
participants).

Exclusion Criteria:

- Change in weight of more than 2 kg over the past 3 months or recent changes in
lifestyle;

- Treatment with a fibrate, thiazolidinedione, insulin, beta-blocker, GLP-1 agonist, or
other drug known to affect lipid or carbohydrate metabolism, except statins,
metformin, sulfonylurea, DPP-IV inhibitor and other antihypertensive agents that can
be temporarily stopped safely prior to the studies, as per our approved protocols;

- Presence of overt cardiovascular, liver, renal or other medical conditions;

- Smoking or consumption of more than 2 alcoholic beverages per day;

- Any other contraindication to temporarily suspending current medications for lipids or
hypertension;

- Any contraindication to MRI scanning.

- Having participated to a research study with exposure to radiation in the last two
years before the start of the study.