Brown Adipose Tissue Metabolism in Type 2 Diabetes
Status:
Recruiting
Trial end date:
2023-12-01
Target enrollment:
Participant gender:
Summary
Activation of brown adipose tissue (BAT) by cold exposure.
BAT thermogenesis and BAT volume of metabolic activity will be assessed by
Positron-Emitting-Tomography (PET/CT) and MRI/MRS imaging and new pharmacological methods to
modulate BAT thermogenesis.
All previous data on the functioning of Brown Adipose Tissue (BAT) were obtained by
Positron-Emitting-Tomography (PET) imaging studies using fluorodeoxyglucose F18 ( [18F]-
FDG). This approach underestimates the actual activity of the BAT. In this study, the
investigator is going to use a new PET tracer (C11-palmitate) which is a fat molecule. This
will allow to quantify more accurately the activity of brown fat.