Overview

Bronchodilator Test in Mechanical Ventilated Chronic Obstructive Pulmonary Disease Patients

Status:
Unknown status

Trial end date:
2015-12-01

Target enrollment:
0

Participant gender:
All

Summary

Investigators developed a test to assess the bronchodilator effects in mechanically ventilated chronic obstructive pulmonary disease patients by comparing the change of airway resistance. No matter whether patients respond to bronchodilator or not, they are randomized assigned to bronchodilator 3-4 times per day group and no bronchodilator group. Then investigators could objectively decide whether individual patients need or benefit from bronchodilator administration.

Phase:

N/A

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Beijing Chao Yang Hospital

Collaborator:

First Affiliated Hospital of Chongqing Medical University

Treatments:

Albuterol
Bronchodilator Agents

Criteria

Inclusion Criteria:

should meet all the criteria:

1. Acute exacerbated chronic obstructive pulmonary disease

2. Invasive mechanical ventilation with intubation outside ICU no more than 48 hours

Exclusion Criteria:

Meet any of the criteria:

1. Asthma

2. Tracheotomy

3. Prolonged Mechanical Ventilation (Have been mechanical ventilated for more than 21
days)

4. Unstable hemodynamic status

5. Severe pneumonia

6. Contraindication for bronchodilator

7. Contraindication for sedation

8. Refusal to participate in study

9. Re-intubation in 48 hours

10. Mental disorder, could not understand and accomplish pulmonary function test