Bronchodilator Responsiveness in Healthy Young Adults Using Forced Oscillations Technique (FOT)
Status:
Completed
Trial end date:
2011-01-01
Target enrollment:
Participant gender:
Summary
Studies evaluating response to bronchodilation in flow-volume spirometry and/or by forced
oscillations technique (FOT), have been conduced in subjects with obstructive airways
diseases. Less is known about bronchodilation responses, assessed by both spirometry and FOT
in healthy young subjects.
The purpose of the present study is
1. to determine the range of the bronchodilation response in terms of changes in selected
spirometric parameters in healthy non-smoking young adults, for identifying normal
response after an inhaled bronchodilatory agent versus placebo, and its anthropometric
and spirometric determinants
2. to determine the range and characteristics of bronchodilation response using
pseudorandom FOT in healthy non-smoking young adults, for identifying normal response
after an inhaled bronchodilatory agent versus placebo, and its anthropometric and
oscillometric determinants.
3. to compare and correlate eventual changes in spirometric and oscillometric parameters.
The investigators hypothesize that exists a normal variation in spirometric and oscillometric
parameters after bronchodilation, and that these parameters are correlated.