Overview
Broncho-alveolar Lavage Under Noninvasive Ventilation With Propofol TCI in Patient With AHRF
Status:
Completed
Completed
Trial end date:
2011-06-01
2011-06-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
Fiberoptic bronchoscopy (FOB) is an important tool for the diagnosis of pulmonary diseases, more particularly in infectious pneumonia. In patients with severe acute hypoxemic respiratory failure, FOB may be contra-indicated until the patient is intubated and control of its oxygenation obtained. In the literature several authors showed that performing FOB under non invasive ventilation (NIV) preserved oxygenation of the patient; and the recent French Consensus on NIV recommends performing FOB under NIV in patients with acute hypoxemic respiratory failure. Nevertheless this procedure remains uncomfortable in most patients with respiratory failure. In addition, patient's agitation may lead to desaturation, and compromise the realization of FOB.Phase:
Phase 3Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
University Hospital, BordeauxTreatments:
Propofol
Criteria
Inclusion Criteria:- Acute respiratory failure defined by clinical signs of respiratory failure (polypnea,
use of accessory respiratory muscle) and a PaO2/FiO2 ratio < 250
- Need for a diagnosis FOB with BAL
- Informed consent signed
Exclusion Criteria:
- Contraindication of NIV
- FOB with bronchial biopsies
- Acute coronary syndrome
- Thrombopenia < 30.000 / mm3 despite platelets transfusion
- Coagulation disorders
- PaO2/FiO2 ratio < 80 under NIV
- Persistent respiratory acidosis under NIV (pH < 7,32)
- Propofol allergy
- Xylocaïne allergy
- Pregnancy
- Age < 18 years or > 90 years
- Weight > 150 kg or < 30 kg
- Inclusion in another clinical protocol