Broad-spectrum Antibiotic Prophylaxis in Tumor and Infected Orthopedic Surgery
Status:
Not yet recruiting
Trial end date:
2024-12-31
Target enrollment:
Participant gender:
Summary
The perioperative antibiotic prophylaxis is evidence-based in orthopedic surgery. While its
duration ranges from a single dose to three doses throughout the world, the choice of the
prophylactic agents is undisputed. Worldwide, the surgeons use 1st or 2nd-generation
cephalosporins (or vancomycin in some cases).
However, there are particular clinical situation with a high risk of antibiotic-resistant
surgical site infections (SSI); independently of the duration of adminis-tered prophylaxis.
These resistant SSI's occur in contaminated wounds, or during surgery under current
therapeutic antibiotics, and base on "selection" by antibiotics used for therapy or for
prophylaxis.