Overview

Brentuximab Vedotin in Refractory/Relapsed Hodgkin Lymphoma Treated by ICE

Status:
Active, not recruiting
Trial end date:
2021-07-01
Target enrollment:
Participant gender:
Summary
This study is designed as a phase Ib/II trial. The first part (phase Ib) is a dose escalation design to explore the safety and assess the recommended phase 2 dose of Brentuximab Vedotin in Hodgkin lymphoma patients treated with ICE regimen. The second part, depending on the selected dose after the completion of phase Ib part of the study, will further explore safety in addition to efficacy of the recommended dose of Brentuximab Vedotin in a selected population of patients treated with ICE with Hodgkin lymphoma.
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
The Lymphoma Academic Research Organisation
Collaborator:
Millennium Pharmaceuticals, Inc.
Treatments:
Antibodies, Monoclonal
Brentuximab Vedotin
Carboplatin
Etoposide
Etoposide phosphate
Ifosfamide
Isophosphamide mustard