Brentuximab Vedotin Plus DHAP in Relapsed or Refractory Hodgkin's Lymphoma
Status:
Recruiting
Trial end date:
2026-03-31
Target enrollment:
Participant gender:
Summary
< STUDY DESIGN > This study is a multi-center phase II trial in patients with relapsed or
refractory Hodgkin's lymphoma after first-line treatment.
< Treatment Schedule >
1. Induction phase
- Patients who sign the informed consent form (ICF) receive BV-DHAP induction therapy
within 21 days.
- Tumor response is evaluated following 2 cycles of induction therapy. As a result of
tumor response evaluation, PD (progressive disease) means a withdrawal from the
study; and CR (complete response), PR (partial response), or SD (stable disease)
requires peripheral blood stem cell collection (PBSCC) followed by additional one
cycle of induction therapy.
- Following a total of 3 cycles of induction therapy, tumor response is evaluated
again. If the result turns out to be CR or PR, treatment goes on to autologous stem
cell transplant (ASCT). SD or PD means a withdrawal from the study.
2. Consolidation phase - ASCT is performed in accordance with a protocol based on the
relevant site's policy.