Breast Cancer Women on Aromatase Inhibitors Treatment
Status:
Recruiting
Trial end date:
2022-12-31
Target enrollment:
Participant gender:
Summary
The main objective of the study is to improve the life quality of women treated with AI.
Cohort B-ABLE is designed to evaluate musculoskeletal events derived of using AI in breast
cancer women. The project objectives are the analysis of the AI deleterious effect on bone
microarchitecture and early determination of the risk of fragility fracture with dual energy
x-ray absorptiometry (DEXA), lumbar spine Rx, Trabecular Bone Score (TBS) and
microindentation. Determination of physiological causes of the AI-related arthralgia by
analyzing joint degradation markers, steroid hormone levels remaining in blood and functional
magnetic resonance, before and after three months of AI treatment