Brassica Vegetables or Indole-3-Carbinol in Treating Patients With PSA Recurrence After Surgery for Prostate Cancer

• Status: Completed
• Trial end date: 2010-11-01
• Target enrollment: 0
• Participant gender: Male

Summary

RATIONALE: Eating a diet high in vegetables may lower the risk of some types of cancer. Brassica vegetables (such as cabbages, kale, broccoli, Brussels sprouts, and cauliflower) and indole-3-carbinol (a substance found in cruciferous vegetables) may help lower the risk of prostate cancer recurrence.

PURPOSE: This randomized clinical trial is studying the side effects and how well Brassica vegetables work compared with indole-3-carbinol in treating patients with PSA recurrence after surgery for prostate cancer.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Vanderbilt University; Vanderbilt University Medical Center
• Collaborator: National Cancer Institute (NCI)
• Treatments: Indole-3-carbinol

Criteria

Inclusion Criteria:

• Diagnosis of prostate cancer with PSA recurrence after prostatectomy

• PSA recurrence is defined as two consecutively rising PSA tests ≥ 8 weeks since the post-surgical nadir, with a minimal interval of 2 weeks between tests and at least 1 PSA test > 0.4 ng/mL

Exclusion Criteria:

• Life expectancy ≥ 9 months

• No predictors of poor adherence (e.g., erratic life-style, mental incompetence)

PRIOR CONCURRENT THERAPY:

• See Disease Characteristics

• No other concurrent Brassica vegetable consumption > 1 serving/day

• No other concurrent indole-3-carbinol supplements

• No endocrine or radiation treatment within past 4 weeks

• No other scheduled treatment during study intervention

• Concurrent prescription medications during the trial allowed

• At least 2 weeks since prior and no concurrent vitamin or herbal supplement use

• Patients refusing to stop non-study supplements will be asked to maintain constant use