Brain Natriuretic Peptide Effects on Appetite Regulating Hormones and Endothelial Derived Peptides

• Status: Completed
• Trial end date: 2011-05-01
• Target enrollment: 0
• Participant gender: Male

Summary

Chronic heart failure is accompanied by anorexia and increased release of B-type natriuretic peptide (BNP) from the ventricular myocytes. The pathophysiological mechanisms linking heart failure and appetite-regulation remain unknown. This study aims to examine the impact of exogenous BNP administration on subjective ratings of hunger and satiety, and on appetite-regulating hormones in a placebo-controlled cross-over study performed in ten healthy human volunteers.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Medical University of Vienna
• Treatments: Hormones; Natriuretic Peptide, Brain

Criteria

Inclusion Criteria:

• Men aged 18 to 40 years

• written informed consent

• BMI < 25 kg/m2

• no concomitant diseases

• BNP level within the normal range

• Normal renal function (serum creatinine of less then 1.2 mg/dL and/or creatinin clearance greater than 80ml/min)

Exclusion Criteria:

• systolic blood pressure < 90 mmHg

• impaired glucose tolerance or diabetes mellitus

• hyperthyroidism, hypothyroidism

• hepatic, renal or cardiovascular diseases

• malignancies

• history of medical therapy within 3 weeks prior to enrolment into the study

• history of anaphylaxis