Brain Mechanisms of Pharmacotherapy in Opioid Use Disorder
Status:
Not yet recruiting
Trial end date:
2027-01-01
Target enrollment:
Participant gender:
Summary
This study will investigate the mechanisms of cognitive-behavioral response to medications
used for relapse prevention in opioid use disorder (opioid addiction, OUD), through
investigation of the neural circuits underlying key cognition functions. The study will use
previously validated cognitive probes, functional Magnetic Resonance Imaging (fMRI), and
novel extended-release injectable preparations of opioid partial agonist buprenorphine and
antagonist naltrexone, in OUD patients to explain the individual heterogeneity of OUD
treatment response.