Brain Mechanisms and Targeting Insomnia in Major Depression
Status:
Unknown status
Trial end date:
2010-02-01
Target enrollment:
Participant gender:
Summary
Preliminary studies suggest that the response to antidepressant medication can be accelerated
by targeting insomnia with adjunctive use of eszopiclone. It is not yet known what
mechanism(s) support this acceleration in response, though preliminary findings support the
hypothesis that early restoration of sleep may facilitate BDNF-based effects of
antidepressant medications. The optimal duration of co-treatment is also unknown. This study
will test specific hypotheses about brain mechanisms and evaluate the effects of continued
eszopiclone beyond the time window when response acceleration should be observed.