Brain Imaging To Examine The Effect Of Naproxen In Hand Osteoarthritis Patients

• Status: Completed
• Trial end date: 2010-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

The study hypothesis is that the relief of pain in patients with osteoarthritis in the hand can be detected by a form of brain scanning that detects which parts of the brain are activated when pain is felt.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Pfizer
• Collaborator: King's College London
• Treatments: Naproxen

Criteria

Inclusion Criteria:

• Right-handed, post-menopausal female, any race, 50-80 years

• Clinical diagnosis of osteoarthritis of the hand

• Estimated pain in this joint of at least 5 on a scale of 0 to 10

Exclusion Criteria:

• Any patient who smokes more than 5 cigarettes per day

• Patients receiving some anti-depressant drugs unless the dose is stable

• Patients unable to be admitted or lie still in an MRI scanner