Overview

Brain Function and Structure in Cocaine Dependence

Status:
Completed
Trial end date:
2016-02-01
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to examine the role of brain MRI findings in predicting treatment outcomes among individuals with cocaine dependence.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Virginia Commonwealth University
Collaborators:
National Institute on Drug Abuse (NIDA)
The University of Texas Health Science Center, Houston
Treatments:
Citalopram
Cocaine
Dexetimide
Criteria
Inclusion Criteria:

- Male and female subjects age 18 to 50 who meet current DSM-IV criteria for cocaine
dependence who are seeking treatment.

Exclusion Criteria:

1. Current DSM-IV diagnosis of any psychoactive substance dependence other than cocaine,
marijuana, nicotine, or alcohol

2. Have a DSM-IV axis I psychiatric disorder or neurological disease or disorder
requiring ongoing treatment and/or making study participation unsafe

3. Significant current suicidal or homicidal ideation

4. Medical conditions contraindicating citalopram pharmacotherapy (liver disease, seizure
disorder, bleeding disorder, or prolonged QT interval on EKG)

5. Taking CNS active concomitant medications

6. Taking medications known to have significant drug interactions with the study
medication

7. Having conditions of probation or parole requiring reports of drug use to officers of
the court

8. Impending incarceration

9. Pregnant or breast feeding for female patients

10. Inability to read, write, or speak English

11. Having plans to leave the immediate geographical area within 3 months

12. Unwillingness or not competent to sign a written informed consent form

13. Individuals who have pacemakers, metal or electromechanical implants or metallic
foreign bodies

14. Patients who are known to be HIV positive will not be included due to possible CNS
effects of HIV.

15. Alcohol withdrawal symptoms or history of significant previous alcohol withdrawal
symptoms.