Overview

BrUOG 379 Phase Ib/II Trial ONC201 + Nivolumab in MSS mCRC

Status:
Active, not recruiting
Trial end date:
2021-12-01
Target enrollment:
Participant gender:
Summary
This is a single arm Phase Ib/II, open label, safety, pharmacokinetic, pharmacodynamics and efficacy study of ONC201 in combination with Opdivo (Nivolumab) in adult patients with metastatic colorectal cancer, for whom no standard therapy is available. This study will enroll adult patients with metastatic colorectal cancer who progressed after at least two lines of therapy.
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
Khaldoun Almhanna
Collaborators:
Bristol-Myers Squibb
Brown University
Oncoceutics, Inc.
Rhode Island Hospital
Treatments:
Antibodies, Monoclonal
Nivolumab
TIC10 compound