Overview

Bowel Function After Minimally Invasive Hysterectomy

Status:
Recruiting
Trial end date:
2023-06-30
Target enrollment:
0
Participant gender:
Female
Summary
Postoperative constipation affects up to a third of women undergoing minimally invasive (MIS) gynecologic surgery and is a major source of anxiety and discomfort. The average time to first bowel movement after gynecologic surgery is about 2 to 4 days and some factors responsible for this include anesthesia inhibitory effect on gastrointestinal motility, opioid pain medication use, chronic NSAID use and anatomic manipulation. There are no established regimens to manage postoperative constipation after minimally invasive gynecologic surgery. Two studies evaluating the implementation of postoperative bowel regimen with polyethylene glycol (PEG) and with Senna and Docusate found no significant impact on postoperative bowel function. There have been no studies looking at the effect of preoperative bowel regimens on postoperative bowel function. The purpose of this study is to evaluate postoperative bowel function after minimally invasive hysterectomy in women receiving a preoperative 10-day bowel regimen of PEG daily.
Phase:
Phase 4
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
University of Chicago
Treatments:
Cathartics
Laxatives
Polyethylene glycol 3350
Criteria
Inclusion Criteria:

- Any woman ≥ 18 years of age undergoing a minimally invasive hysterectomy
(Laparoscopic, robotic, vaginal)

- Able to understand the consenting process and willing to participate in study

Exclusion Criteria:

- Planned laparotomy

- Emergent surgery

- Regular preoperative use of PEG 3350, laxatives, enemas or suppositories

- Planned bowel surgery

- Presence of colostomy

- Inability to consent

- Medical problems as follows:

- CKD (Cr: > 1.2 mg/dL)

- IDDM

- Cardiac disease

- Gastric ulcers

- Difficulty swallowing or esophageal stricture

- Persistent nausea or vomiting

- Signs or symptoms of a small bowel obstruction