Bovine Lactoferrin and Neonatal Survival in Low Birth Weight Babies.
Status:
Recruiting
Trial end date:
2020-05-01
Target enrollment:
Participant gender:
Summary
Pakistan has the third highest number of neonatal deaths worldwide. During the last two
decades (1990-2013), neonatal mortality rate in the country has declined by only 1.0% per
year. Severe infection is the second most leading cause of neonatal mortality, account for
28% of all deaths in Pakistan. Majority of neonatal deaths occur in infants who LBW (birth
weight <2500g) and LBW comprises of both preterm / small for gestational age newborns.
Breastfeeding helps protect infants from infections by serving as a source of nutrition
uncontaminated by environmental pathogens. The protection is due to the multiple
anti-infective, anti-inflammatory, and immuno regulatory factors transmitted through milk
including secretory antibodies, glycan's, Lactoferrin, leukocytes, cytokines & other
components produced by the mother's immune system.
Reduction in neonatal infections and deaths is the aim of this study. The study is being
conducted at the Aga Khan University in collaboration with University of Sydney.
Phase:
Phase 3
Details
Lead Sponsor:
Aga Khan University
Collaborators:
United States Agency for International Development (USAID) University of Sydney