Botulinum Toxin to Improve Results in Cleft Lip Repair
Status:
Unknown status
Trial end date:
2013-08-01
Target enrollment:
Participant gender:
Summary
Botulinum toxin type A (Botox; Allergan, Inc., Irvine, Calif) is widely used for facial
rejuvenation and many other medical indications. It induces chemodenervation through its
action on the presynaptic neuron, preventing release of acetylcholine, which leads to
functional denervation of striated muscle for 2 to 6 months after injection. The use of
botulinum toxin injection to reduce the facial scar is logical because this could reduce the
tensile distracting force of the upper lip caused by the orbicularis oris muscle pull.
Tollefson has demonstrate that botulinum toxin injection has decrease lip tension after
primary lip repair in 3 children at 3-6 months of age The main aim of this randomized trial
is to compare whether post-operative peri-surgical-injection of botulinum toxin into
bilateral orbicularis oris muscles can improve scar formation for both primary and secondary
cleft lip surgery.
Phase:
Phase 3
Details
Lead Sponsor:
Chang Gung Memorial Hospital
Treatments:
abobotulinumtoxinA Botulinum Toxins Botulinum Toxins, Type A incobotulinumtoxinA onabotulinumtoxinA