Preclinical studies at our institution, using a genetic mouse model of gastric cancer,
strongly suggest that innervation of the stomach wall is required not only for the
development, but also for the progression of gastric cancer, and that denervation of the
stomach either by vagotomy or by injection of botulinum toxin (Botox®) in the stomach wall
may represent an effective therapeutic intervention. New treatment options for inoperable
cancer in the stomach are urgently needed, and local treatment with botulinum toxin seems to
be an attractive possibility. In this pilot study Botox injections will be given by
gastroscopy in both the tumor and the surrounding stomach wall. The purpose of the study is
to obtain data needed to calculate sample size in a larger controlled trial.
Phase:
Phase 2
Details
Lead Sponsor:
St. Olavs Hospital
Collaborator:
Norwegian University of Science and Technology
Treatments:
abobotulinumtoxinA Botulinum Toxins Botulinum Toxins, Type A incobotulinumtoxinA onabotulinumtoxinA