Botulinum Toxin Injections by Ultrasounds Guidance and Stretching Exercise in Spastic Toe Clawing

• Status: Completed
• Trial end date: 2013-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Claw toes deformity result in spasticity often seem in patients with central nerve disease. It also cause pressure sore in foot and pain during walking that didn't well improve under traditional treatment. There are few relative reports about the Botulinum toxin type A (BTX-A) injection on claw toe. The investigators' study has two main purposes:

1. assess the efficiency of BTX-A injection under ultrasonographyic guidance on improving lower extremities function, pain and spasticity in patients with symptomatic claw toes.

2. assess if regular stretching exercise can strength the efficiency of BTX-A injection on improving lower extremities function, pain and spasticity.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Chang Gung Memorial Hospital
• Treatments: abobotulinumtoxinA; Botulinum Toxins; Botulinum Toxins, Type A; incobotulinumtoxinA; onabotulinumtoxinA

Criteria

Inclusion Criteria:

• Patient with spasticity toe clawing(metatarsophalange jointextension, proximal and distal phalange joint flexion)

• MAS scale of metatarsophalange joint and interphalangeal joint more than 2

• Pain during walking, abnormal gait patterns and can't wear shoess due to claw toe

• Haven't received botox or phenol or alcohol injections before

Exclusion Criteria:

• Lower extremities joint contrature, bone deformity

• Had received botox injections or phenol injections or before due to lower extremities spasticity

• Combine other neuromuscular system disease

• Severe cognition disorder or aphasia after stroke

• Significant atrophy of flexor digitorum longus and brevis

• Allergy to botox

• Infection on injection site

• Have systemic infection

• Now accept aminioglycoside or other medicine will affect neuromusclar transition