Botulinum Toxin A to Treat Flexion Contracture After Total Knee Arthroplasty
Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
The goal of this research project is to evaluate injections of botulinum toxin A (Botox) as
the treatment for knee flexion contracture after total knee arthroplasty (TKA). The current
treatment for patients who do not achieve full extension of the knee (flexion contracture)
after TKA consists of an aggressive physical therapy program, home stretching program, and
the use of an extension orthosis (brace). Many patients do not tolerate wearing these braces.
This initial project is designed to use injections of Botox as an adjunct to the standard
current treatment and evaluate its efficacy. It is our hypothesis that a single injection
into the hamstrings in addition to routine postoperative rehabilitation will result in
improved knee extension and this improvement in function should endure without further
treatment.
Phase:
N/A
Details
Lead Sponsor:
Rothman Institute Orthopaedics
Collaborator:
Sharpe-Strumia Research Foundation
Treatments:
abobotulinumtoxinA Botulinum Toxins Botulinum Toxins, Type A incobotulinumtoxinA onabotulinumtoxinA