Shoulder pain after stroke is a very common, causing significant morbidity disease.
Subacromial and subdeltoid (SASD) bursitis are common causes of pain or disability of the
shoulder joint in stroke patients. Traditional therapeutic approaches for the shoulder pain
therapy including pharmacotherapy, injection therapy, physical therapy, and behavioural
modification. Unfortunately, these therapy methods may not be effective in many patients and
long term benefit after treatment is transient, the outcomes may also be incomplete or
non-existent. Botulinum toxin A (BoNT-A) is a neurotoxin that can inhibit not only the
acetylcholine at the neuromuscular junctions but also other neurotransmitters such as
glutamate, substance P and calcitonin gene related peptide, all of which have been indicated
in pain transmission. Despite the therapeutic benefit of BTX in alleviating painful muscle
spasms, its efficacy in SASD bursitis conditions is less clear. So we perform this study to
examine the efficacy of ultrasound guided SASD injection with BoNT-A in reducing refractory
shoulder pain after stroke.
Phase:
Phase 4
Details
Lead Sponsor:
Sir Run Run Shaw Hospital
Treatments:
abobotulinumtoxinA Botulinum Toxins Botulinum Toxins, Type A incobotulinumtoxinA onabotulinumtoxinA Triamcinolone Triamcinolone Acetonide Triamcinolone diacetate Triamcinolone hexacetonide