Bosentan Treatment of Digital Ulcers Related to Systemic Sclerosis
Status:
Completed
Trial end date:
2019-06-30
Target enrollment:
Participant gender:
Summary
GRegistry is a significant collection of data and information on the clinical practice of
systemic scleroderma finger ulcers.
The GRegistry study is a nationwide (Greece) prospective study recording, which includes
consecutive patients with SC-DU diagnosis in clinical management departments of different
hospitals, selected in such a way as to reflect a representation of the country.
The use of Bosentan in the treatment of patients suffering from systemic sclerosis with
digital ulcer disease is supported by data from large, placebo-controlled, randomized
studies. The beneficial effect of Bosentan in digital ulcers, a vascular event of systemic
sclerosis consistent with its beneficial effect on pulmonary arterial hypertension associated
with connective tissue disease and its beneficial effect on vascular remodeling.