Bortezomib and Temozolomide in Treating Patients With Brain Tumors or Other Solid Tumors That Have Not Responded to Treatment

• Status: Completed
• Trial end date: 2012-01-01
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Bortezomib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving bortezomib together with temozolomide may kill more tumor cells.

PURPOSE: This phase I trial is studying the side effects and best dose of bortezomib when given together with temozolomide in treating patients with brain tumors or other solid tumors that have not responded to treatment.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: City of Hope Medical Center
• Collaborator: National Cancer Institute (NCI)
• Treatments: Bortezomib; Dacarbazine; Temozolomide

Criteria

DISEASE CHARACTERISTICS:

• Histologically or cytologically confirmed solid tumors including the following

• Recurrent high-grade glioma

• Recurrent metastatic brain tumors

• Recurrent primary brain tumor including primary CNS lymphoma

• Other refractory solid tumors

• Unresectable disease for which standard curative or palliative measures do not exist or are no longer effective

• Measurable or nonmeasurable disease

PATIENT CHARACTERISTICS:

Inclusion criteria:

• Karnofsky performance status 60-100%

• Absolute neutrophil count ≥ 1,500/mm^3

• Platelet count ≥ 100,000/mm^3

• Serum creatinine ≤ 1.5 x upper limit of normal (ULN)

• Total bilirubin ≤ 2.0 mg/dL

• AST ≤ 4.0 x ULN

• Not pregnant or nursing

• Negative pregnancy test

• Fertile patients must use effective contraception

• Patient must be able to understand and is willing to sign a written informed consent document

Exclusion criteria:

• Any of the following conditions:

• Myocardial infarction within the past 6 months or New York Heart Association class III or IV heart failure

• Uncontrolled angina

• Severe uncontrolled ventricular arrhythmias

• ECG evidence of acute ischemia or active conduction system abnormalities

• Any ECG abnormalities prior to study entry must be documented by the investigator as not medically relevant

• Serious medical or psychiatric illness that would, in the opinion of the investigator, potentially interfere with the completion of treatment

• History of sensitivity to boron or mannitol

PRIOR CONCURRENT THERAPY:

Inclusion criteria:

• At least 4 weeks since prior chemotherapy (6 weeks for nitrosourea-containing chemotherapy), immunotherapy, or radiotherapy and recovered

• More than 10 days since prior anticonvulsant drugs that induce hepatic metabolic enzymes for patients in group A

• Recovered from major surgery

• Corticosteroids for cerebral edema allowed provided the patient is on a stable dose for at least 1 week

Exclusion criteria:

• Patients enrolled on another clinical trial

• HIV-positive patients on antiretroviral therapy

• Concurrent chemotherapy or radiotherapy

• Patient requires anti-seizure medication but is not on a stable dose and agent of anti-seizure medication