Bortezomib and Temozolomide in Treating Patients With Advanced Refractory Solid Tumors or Melanoma
Status:
Terminated
Trial end date:
2008-03-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy, temozolomide, work in different ways to stop the
growth of tumor cells, either by killing the cells or stopping them from dividing. Bortezomib
may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Giving temozolomide together with bortezomib may kill more tumor cells.
PURPOSE: To determine the best dose of bortezomib and temozolomide and to see how well they
work in treating patients with advanced refractory solid tumors or melanoma.