Overview

Bortezomib and Combination Chemotherapy in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma

Status:
Completed
Trial end date:
2014-09-01
Target enrollment:
0
Participant gender:
All
Summary
This pilot, phase II trial studies the side effects of giving bortezomib together with combination chemotherapy and to see how well it works in treating young patients with relapsed acute lymphoblastic leukemia or lymphoblastic lymphoma. Bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving bortezomib together with combination chemotherapy may kill more cancer cells.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
National Cancer Institute (NCI)
Treatments:
Asparaginase
Bortezomib
Cortisol succinate
Cyclophosphamide
Cytarabine
Doxorubicin
Etoposide
Etoposide phosphate
Hydrocortisone
Hydrocortisone 17-butyrate 21-propionate
Hydrocortisone acetate
Hydrocortisone hemisuccinate
Leucovorin
Levoleucovorin
Liposomal doxorubicin
Methotrexate
Pegaspargase
Prednisone
Vincristine
Criteria
Inclusion Criteria:

- Diagnosis

- Pre-B ALL in first early (< 36 months from diagnosis) isolated bone marrow (BM)
or combined BM/extramedullary relapse; or

- T-cell ALL in first isolated BM or combined relapse; or

- T-LL in first relapse

- Patients with leukemia must have had histologic verification of the malignancy at
relapse, including immunophenotyping to confirm diagnosis

- Patients with lymphoblastic lymphoma must have measurable disease documented by
clinical, radiographic, or histologic criteria; patients must have relapsed or become
refractory to conventional therapy

- Patients must have a performance status corresponding to Eastern Cooperative Oncology
Group (ECOG) scores of 0, 1 or 2; use Karnofsky for patients > 16 years of age and
Lansky for patients =< 16 years of age

- Patients who relapse while receiving standard ALL maintenance chemotherapy will not be
required to have a waiting period before entry onto this study

- Patients who relapse on therapy other than standard ALL maintenance therapy must have
fully recovered from the acute toxic effects of all prior chemotherapy, immunotherapy,
or radiotherapy prior to entering this study

- At least 14 days since the completion of cytotoxic therapy with the exception of
hydroxyurea, which is permitted up to 24 hours prior to the start of protocol therapy

- At least 7 days since the completion of therapy with a biologic agent or donor
lymphocyte infusions (DLI); for agents that have known adverse events occurring beyond
7 days after administration, this period must be extended beyond the time during which
adverse events are known to occur

- No evidence of active graft-vs-host disease (GVHD) and >= 4 months must have elapsed;
must not be receiving GVHD prophylaxis

- Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70
mL/min/1.73 m^2 or a serum creatinine based on age/gender as follows:

- 1 month to < 6 months (0.4 male, 0.4 female)

- 6 months to < 1 year (0.5 male, 0.5 female)

- 1 to < 2 years (0.6 male, 0.6 female)

- 2 to < 6 years (0.8 male, 0.8 female)

- 6 to < 10 years (1 male, 1 female)

- 10 to < 13 years (1.2 male, 1.2 female)

- 13 to < 16 years (1.5 male, 1.4 female)

- >= 16 years (1.7 male, 1.4 female)

- Total bilirubin =< 1.5 x upper limit of normal (ULN) for age

- Serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) < 3 x
ULN for age, unless elevation due to leukemia infiltration

- Shortening fraction of >= 27% by echocardiogram, or

- Ejection fraction of >= 50% by gated radionuclide study

- No evidence of dyspnea at rest, no exercise intolerance, and a pulse oximetry >= 94%
at sea level (> 90% if at high altitude)

- No evidence of acute pulmonary infiltrates on chest radiograph

- Patients with seizure disorder may be enrolled if on allowed anticonvulsants and well
controlled; benzodiazepines and gabapentin are acceptable

- Central nervous system (CNS) toxicity =< grade 2

- Peripheral nervous system (PNS) toxicity < grade 3

- All patients and/or their parents or legal guardians must sign a written informed
consent

- All institutional, FDA, and National Cancer Institute (NCI) requirements for human
studies must be met

Exclusion Criteria:

- Patients with Philadelphia chromosome positive ALL are not eligible unless refractory
to at least one tyrosine kinase inhibitor (TKI) therapy; patients that are unable to
tolerate TKI therapy due to toxicity are eligible

- Patients with mature B-cell ALL, ie, leukemia with B-cell (soluble immunoglobulin
[sIg] positive and kappa or lambda restricted positivity) ALL, with
French-American-British (FAB) L3 morphology and/or a myc translocation, are not
eligible

- Extramedullary disease status: patients with isolated CNS disease or isolated
testicular disease are not eligible

- Patients with known optic nerve and/or retinal involvement are not eligible; patients
presenting with visual disturbances should have an ophthalmological exam and, if
indicated, an magnetic resonance imaging (MRI) to determine optic nerve or retinal
involvement

- Patients with concomitant genetic syndrome: patients with Down syndrome, Fanconi
anemia, Kostmann syndrome, Shwachman syndrome or any other known bone marrow failure
syndrome are not eligible

- Cumulative prior anthracycline exposure must not exceed 400 mg/m^2

- Patients taking anticonvulsants known to activate the cytochrome p450 system, in
particular anticonvulsants such as phenytoin, carbamazepine, and phenobarbital, are
not eligible; benzodiazepines and gabapentin are acceptable

- Patients who have previously received bortezomib or other proteasome inhibitors are
not eligible

- Patients who have a known allergy to doxorubicin, cytarabine, both etoposide and
etopophos, boron, mannitol or bortezomib are not eligible

- Patients who cannot receive any asparaginase products (E. Coli, PEG-asparaginase, or
Erwinia asparaginase) on this study (eg, due to prior severe pancreatitis, stroke or
other toxicity) are not eligible; patients who initially receive asparaginase, but
must discontinue due to toxicity, remain eligible; patients with clinically
significant prior allergies to pegaspargase are eligible if Erwinia L-asparaginase can
be substituted

- Patients who are pregnant or breast-feeding are not eligible for this study; negative
pregnancy tests must be obtained in girls who are post-menarchal; males or females of
reproductive potential may not participate unless they have agreed to use an effective
birth control method

- Patients must not have received any prior re-induction attempts and must not have
received treatment for prior extramedullary relapse; patients with primary induction
failure are not eligible