Bortezomib, Fluorouracil, Leucovorin, and Oxaliplatin in Treating Patients With Advanced or Metastatic Colorectal Cancer
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy, such as fluorouracil, leucovorin, and oxaliplatin,
work in different ways to stop the growth of tumor cells, either by killing the cells or by
stopping them from dividing. Bortezomib may stop the growth of tumor cells by blocking some
of the enzymes needed for cell growth. It may also help the chemotherapy drugs work better by
making tumor cells more sensitive to the drugs. Giving bortezomib with fluorouracil,
leucovorin, and oxaliplatin may kill more tumor cells.
PURPOSE: This phase I trial is studying the side effects and best dose of bortezomib when
given with fluorouracil, leucovorin, and oxaliplatin in treating patients with advanced or
metastatic colorectal cancer.
Phase:
Phase 1
Details
Lead Sponsor:
European Organisation for Research and Treatment of Cancer - EORTC