Overview

Boron Neutron Capture Therapy in Treating Patients With Glioblastoma Multiforme or Melanoma Metastatic to the Brain

Status:
Completed
Trial end date:
2005-01-01
Target enrollment:
0
Participant gender:
All
Summary
RATIONALE: Radiation therapy such as boron neutron capture therapy may kill tumor cells without harming normal tissue. PURPOSE: Phase I/II trial to study the effectiveness of boron neutron capture therapy in treating patients who have glioblastoma multiforme or melanoma metastatic to the brain.
Phase:
Phase 1/Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Beth Israel Deaconess Medical Center
Collaborator:
National Cancer Institute (NCI)
Criteria
DISEASE CHARACTERISTICS:

- Histologically confirmed glioblastoma multiforme OR

- Radiographically diagnosed brain metastases after a diagnosis of melanoma

- Contrast-enhanced tumor volume must not exceed 60 mL

PATIENT CHARACTERISTICS:

Age:

- 18 and over

Performance status:

- ECOG 0-2

Life expectancy:

- At least 6 months

Hematopoietic:

- Not specified

Hepatic:

- Not specified

Renal:

- Creatinine normal

Cardiovascular:

- No prior severe cardiac disease, including the following:

- Uncontrolled arrhythmias or conduction defects

- Unstable or newly diagnosed angina pectoris

- Recent coronary artery disease

- Congestive heart failure

Other:

- Not pregnant

- Negative pregnancy test

- Fertile patients must use effective contraception during and for at least 6 months
after study

- No prior phenylketonuria

- No cognitive impairment that would preclude informed consent

PRIOR CONCURRENT THERAPY:

Biologic therapy:

- Not specified

Chemotherapy:

- No concurrent chemotherapy

Endocrine therapy:

- Not specified

Radiotherapy:

- No prior cranial irradiation

Surgery:

- Not specified