Bone Properties in Hypoparathyroidism: Effects of PTH
Status:
Completed
Trial end date:
2014-06-01
Target enrollment:
Participant gender:
Summary
Whereas much information is known about the properties of bone in primary
hyperparathyroidism, a disorder of parathyroid hormone (PTH) excess, virtually nothing is
known about the skeleton in hypoparathyroidism, a disorder in which PTH is absent. The
purpose of this research project is to test the hypothesis that the skeleton in
hypoparathyroidism is abnormal in its metabolic, densitometric, geometric, biomechanical and
microarchitectural features. We will also test the hypothesis that the skeleton is dependent
upon PTH for normal structure and function. Using non-invasive approaches as well as direct
analysis of bone itself, the human hypoparathyroid skeleton will be thoroughly characterized.
With each patient serving as his/her own control, we will determine how, to what extent, and
in what ways the administration of PTH restores skeletal dynamics and structure to the
hypoparathyroid skeleton. In this way, we will identify those structural and dynamic elements
of the skeleton that are influenced by or dependent upon PTH. Methods to be utilized include
dual energy X-ray absorptiometry, quantitative central and peripheral computed tomography,
geometry and size quantification, histomorphometry by standard and microCT methods, finite
element analysis, biochemical bone markers, quantitative back scattered electron imaging, and
Fourier Transform Infrared Spectroscopy. This research project will extend our knowledge of
the skeletal effects of PTH to its deficient range and thus complete our understanding of PTH
action on bone gained by our many years of studying PTH overexpression in primary
hyperparathyroidism. This investigation may also provide insight into the means by which PTH
helps to restore the skeleton when it is used to treat osteoporosis.
Phase:
Phase 2/Phase 3
Details
Lead Sponsor:
John P. Bilezikian
Collaborator:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)