Bone Mesenchymal Stem Cell (BMSC) Transplantation in Liver Cirrhosis Via Portal Vein
Status:
Unknown status
Trial end date:
2011-04-01
Target enrollment:
Participant gender:
Summary
The objective of this study is to evaluate the therapeutic efficacy of autologous bone marrow
mesenchymal stem cells (BMSCs) transplantation via portal vein in patients with early and
middle stage of liver cirrhosis on the basis of HBV infection. The evaluation of the efficacy
includes the level of serum alanine aminotransferase (ALT), aspartate aminotransferase(AST),
total bilirubin (TB),prothrombin time (PT), albumin (ALB), prealbumin(PA), precollagenⅢ(PCⅢ),
collagenⅣ(Ⅳ-C), laminin(LN), hyaluronidase(HN), liver histological improvement before and 1
week to 1 year after transplantation. Child-Pugh scores and clinical symptoms were also
observed simultaneously.