Bone Marrow Progenitor Cell Mobilization in Diabetes
Status:
Completed
Trial end date:
2013-08-01
Target enrollment:
Participant gender:
Summary
Diabetes mellitus is associated with a significant reduction of circulating progenitor cells
(CPCs). These include endothelial progenitor cells (EPCs), which are involved in
cardiovascular homeostasis and repair. A reduction of CPCs in metabolic patients is
associated with an increased risk of future adverse cardiovascular outcomes. Therefore, ways
to active stimulate an increase of CPC levels in diabetes are actively pursued.
Experimental animal studies and preliminary data in humans indicate that a bone marrow defect
is causally related to the low CPC level in diabetes.
Our previous data in rats indicate that diabetes reduces the bone marrow responsiveness to
granulocyte colony-stimulating factor (G-CSF) in terms of progenitor cell mobilization.
In the present study, we aim at investigating bone marrow responsiveness to pharmacological
mobilization of CPC in diabetic patients as compared to non-diabetic subjects.