Bone Marrow Derived Adult Stem Cells for Chronic Heart Failure
Status:
Completed
Trial end date:
2013-05-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine whether adult bone marrow derived stem/progenitor
cells improve cardiac function and symptoms in patients with heart failure and to establish
the optimal method of delivery of these cells.
Study hypotheses:
- Administration of G-CSF to patients with heart failure secondary to ischaemic heart
disease will lead to an increase in circulating progenitor cells as measured by
peripheral CD34+ positive cell counts
- Cardiac function and symptoms will improve in patients in whom the peripheral CD34+
counts increase in response to G-CSF administration
- Direct coronary injection of autologous bone marrow derived stem cells will confer an
additional improvement in cardiac function and symptoms above that derived from G-CSF
infusion alone
- Direct intramyocardial injection of autologous bone marrow derived stem cells will lead
to an improvement in cardiac function and symptoms above that derived from G-CSF
infusion alone