Body Weight, Sleep, and Heart Health

• Status: Recruiting
• Trial end date: 2021-05-31
• Target enrollment: 0
• Participant gender: All

Summary

A multidisciplinary investigation examining the circadian mechanisms regulating cardiovascular (CV) risk in obesity. Specifically, in a valid circadian protocol, the investigators aim to study resting cardiovascular risk markers and the reactivity of circadian rhythms in these risk markers to standardized stressors in obesity. Furthermore, using an ingenious approach, the investigators propose to explore impairment in pre/post synaptic function in the cardiac left ventricle.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Oregon Health and Science University
• Treatments: CGP 12177

Criteria

Inclusion Criteria:

• Ages 25-65

• Lean and overweight (BMI 18.5-40kg/m2)

• Habitually sedentary

Exclusion Criteria:

• History of smoking/tobacco use

• Insomnia

• Moderate to severe obstructive sleep apnea.

• Prior shift work within 6 months prior to the study.

• Prescription medications

• Drugs of abuse

• Acute, chronic, or debilitating medical condition (including diabetes, hypertension, and metabolic syndrome)