Blood Pressure and Brain Blood Flow Regulation After Midodrine Administration in Those With Spinal Cord Injury
Status:
Completed
Trial end date:
2013-11-01
Target enrollment:
Participant gender:
Summary
This project aims to evaluate the physiological effects of Midodrine administration during
orthostatic challenge in those with high level spinal cord injury. Midodrine has been shown
to improve orthostatic symptoms in those with spinal cord injury but the physiological
mechanisms influenced have not been identified. The investigators will examine key
physiological components influencing orthostatic tolerance. The investigators will do this,
by measuring the baroreflex, and brain blood flow autoregulation (the ability to maintain
brain blood flow) before during and after the sit-up test. Two sit-up tests will occur; one
before Midodrine administration, and one after administration of a 10mg dose of Midodrine.