Cerebral vasodilator responses to CO2 will be measured in young healthy adults, healthy
sedentary older adults, and healthy exercise trained older adults. This variable will be
examined before and after administering the cyclooxygenase inhibitor indomethacin, which has
been shown to blunt cerebral vasodilator responses. In addition, the investigators will
examine these counter-regulatory hemodynamic mechanisms to hypoperfusion caused by
indomethacin.
Phase:
Early Phase 1
Details
Lead Sponsor:
University of Wisconsin, Madison
Collaborators:
National Heart, Lung, and Blood Institute (NHLBI) National Institutes of Health (NIH)