Blockade of Vascular Potassium Channels During Human Endotoxemia
Status:
Completed
Trial end date:
2005-06-01
Target enrollment:
Participant gender:
Summary
Background: Activation of NO-synthase and vascular potassium (K) channels may play a role in
the sepsis-induced attenuated sensitivity to norepinephrine. We examined whether various K
channel blockers and NO-synthase inhibition could restore norepinephrine sensitivity during
experimental human endotoxemia.
Phase:
Phase 1
Details
Lead Sponsor:
Radboud University
Collaborator:
ZonMw: The Netherlands Organisation for Health Research and Development