Overview

Blinatumomab in Treating Younger Patients With Relapsed B-cell Acute Lymphoblastic Leukemia

Status:
Active, not recruiting
Trial end date:
2022-06-30
Target enrollment:
Participant gender:
Summary
This randomized phase III trial studies how well blinatumomab works compared with standard combination chemotherapy in treating patients with B-cell acute lymphoblastic leukemia that has returned after a period of improvement (relapsed). Immunotherapy with blinatumomab, may induce changes in body's immune system and may interfere with the ability of tumor cells to grow and spread. It is not yet known whether standard combination chemotherapy is more effective than blinatumomab in treating relapsed B-cell acute lymphoblastic leukemia.
Phase:
Phase 3
Details
Lead Sponsor:
National Cancer Institute (NCI)
Treatments:
2-Aminopurine
6-Mercaptopurine
Antibodies
Antibodies, Bispecific
Antibodies, Monoclonal
Antineoplastic Agents, Immunological
Asparaginase
BB 1101
Blinatumomab
Calcium
Calcium, Dietary
Cortisol succinate
Cyclophosphamide
Cytarabine
Dexamethasone
Dexamethasone 21-phosphate
Dexamethasone acetate
Etoposide
Etoposide phosphate
Folic Acid
Hydrocortisone
Hydrocortisone 17-butyrate 21-propionate
Hydrocortisone acetate
Hydrocortisone hemisuccinate
Immunoglobulins
Leucovorin
Levoleucovorin
Mercaptopurine
Methotrexate
Mitoxantrone
Muromonab-CD3
Pegaspargase
Podophyllotoxin
Thioguanine
Vincristine