One of the most important neurological consequences following Traumatic Brain Injury (TBI) is
the development of post traumatic epilepsy (PTE). Nevertheless, there is still no effective
therapeutic intervention to reduce the occurrence of PTE. In previous studies with animals
models of epilepsy, the biperiden decreased the incidence and intensity of spontaneous
epileptic seizures besides delaying their appearance. The aim of this study is the evaluation
of biperiden as antiepileptogenic drug to prevent PTE and also the determination of side
effects, evaluating its cost-effectiveness in patients with moderate and severe TBI.