The investigator would like to see if aspirin could block niacin-induced flushing by
analyzing blood and urine after taking aspirin.
Phase I: Subjects were assigned to either placebo or aspirin groups. They were given 5 days
of 81 mg aspirin or placebo. On day 5, they were given a single dose of niacin (600 mg)
administered 30 minutes after the last dose of aspirin or placebo. The same subjects came
back for cross-over study and were assigned to a different group. There was a 2-week washout
period between each treatment. Urine was collected sequentially for analysis
Phase II: The same study subjects come back for an open label one week study. They were given
5 days of taking 81 mg Aspirin, taken once daily, followed by a single dose of 600 mg Niacin
on day 6. Urine was collected sequentially for analysis