Chronic shoulder pain is a common, costly, and disabling problem for society. The
identification of factors predictive of the development of chronic shoulder pain is necessary
to develop innovative and effective treatments to reduce the societal impact of shoulder
disorders. In previous work the investigators identified a genetic and psychological subgroup
that robustly predicted heightened shoulder pain responses in a pre-clinical cohort and poor
12 month shoulder pain recovery rates in a clinical surgical cohort. In this follow-up study
the investigator proposes to test how interventions tailored to the high risk subgroup affect
pain responses in a pre-clinical cohort.
The optimal theorized match for the identified high-risk subgroup is a combination of
personalized pharmaceutical and education interventions. This combined personalized
intervention versus a placebo pharmaceutical and general education intervention group is the
primary comparison of interest. Also, an evaluation of the individual effect of personalized
pharmaceutical and educational interventions will be part of the study. Such comparisons will
provide important information on what the active portion of the combined personalized
intervention may be.
Phase:
Phase 2
Details
Lead Sponsor:
Duke University University of Florida
Collaborators:
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) National Institutes of Health (NIH)