Biomarkers in Obese Patients With Knee Osteoarthritis; Weight Maintenance
Status:
Completed
Trial end date:
2019-03-01
Target enrollment:
Participant gender:
Summary
This is a substudy to a randomized trial investigating the effect of liraglutide on body
weight and pain in overweight or obese patients with knee osteoarthritis (NCT02905864). In
the parent trial, patients will be subjected to an 8-week diet intervention phase including a
low-calorie diet and dietetic counseling, after which they will be randomized to receive
either liraglutide 3 mg or liraglutide 3 mg placebo as an add-on to dietetic guidance on
re-introducing regular foods and a focus on continued motivation to engage in a healthy
lifestyle.
This substudy aims to investigate the impact of, and subsequent change of biomarkers in obese
patients with knee osteoarthritis following a randomization to Liraglutide 3 mg or
Liraglutide 3 mg placebo treatment between weeks 0-52.