Biological Effects of Citrate-buffered Solutions on Dialysis Efficiency and Systemic Inflammation
Status:
Completed
Trial end date:
2015-07-30
Target enrollment:
Participant gender:
Summary
In this study 45 patients undergoing weekly dialysis for chronic end stage renal disease will
be enrolled. The patients will be treated with a standard dialysis solution, containing
acetate buffer, for 3 months; subsequently the acetate will be substituted with citrate anion
for the 3 following months and then, the last 3 months, the standard acetate-solution will be
restarted. The aim of the study is to assess if acetate-to-citrate switch in the dialysis
solution influences dialysis efficiency and patient inflammatory state.
Phase:
Phase 2/Phase 3
Details
Lead Sponsor:
Azienda Ospedaliera Città della Salute e della Scienza di Torino