Bioavailability of Paracetamol, Amoxicillin and Talinolol Before, Immediately and One Year After Gastric Bypass Operation
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
The purpose of this study is to evaluate pharmacokinetics of paracetamol, amoxicillin and
talinolol in morbid adipose subjects before as well as shortly after and about one year after
proximal Roux-en-Y Gastric Bypass (RYGB) and to measure messenger ribonucleic acid (mRNA)
expression and protein content of duodenal and/or jejunal drug metabolizing enzymes (eg.
cytochrome P450 isoenzyme 3A4 (CYP3A4), uridine diphosphoglucuronosyltransferase (UGTs)) and
drug transport proteins (e.g. P-glycoprotein, MRP2, OATPB, PEPT) before and during the
operation and about one year after proximal RYGB.