Bilateral Transversus Abdominis Plane Block With or Without Magnesium

• Status: Recruiting
• Trial end date: 2021-01-01
• Target enrollment: 0
• Participant gender: Female

Summary

Pain control after surgery is important for patient well-being and recovery. We are interested in determining whether we can improve the duration of action of a local anesthetic procedure (transversus abdominis plane block, or TAP block) by adding magnesium sulfate to local anesthetics given to patients after total abdominal hysterectomy with or without salpingo-oophorectomy.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Dr. Anthony Ho; Queen's University
• Treatments: Magnesium Sulfate; Ropivacaine

Criteria

Inclusion Criteria:

• American Society of Anesthesiologists (ASA) rating I-III

• Age 18-75 years old

• Female

• Undergoing elective total abdominal hysterectomy (TAH) with or without uni/bilateral salpingo-oophorectomy (BSO) under general anesthesia with a Pfannenstiel incision

• Admitted to hospital postoperatively (inpatients)

• Competent to provide informed consent

Exclusion Criteria:

• Emergency TAH ± BSO

• ASA IV-V

• Allergy or sensitivity to study-related medications

• Taking any medications that are contraindicated for the use of any of our study drugs

• Midline incision

• Other regional anesthesia technique (e.g. epidural)

• Morbidly Obese (BMI > 40)

• Incompetent to provide informed consent

• eGFR < 50

• Impaired liver function (INR > 1.5)

• Pre-existing chronic pain condition requiring chronic opioid use

• Significant co-existing cardiovascular disease