Bicarbonate v Saline to Prevent Contrast Nephropathy

• Status: Terminated
• Trial end date: 2009-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Slowing of kidney function occurs in a minority of people given dye during angiography. The purpose of this study is to compare two different types of fluid given into a vein to reduce the risk of kidney injury: salt in water or baking soda in water.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Italian Society of Nephrology
• Collaborators: European Commission; Memorial University of Newfoundland

Criteria

Inclusion Criteria:

• Booked for cardiac or other non-renal arteriography

• Pre-existing reduced kidney function: Serum Creatinine >= 1.3 & <= 4 mg/dl (female gender) or >= 1.5 & <= 5 mg/dl (male gender)

• Age > 18 years

Exclusion Criteria:

• GFR MDRD estimate < 15 ml/min/m2

• End-stage renal disease already on dialysis

• Known current Acute Kidney Failure with serum creatinine rise of > 0.5 mg/dl within 24 hours

• Pulmonary edema - current or within 48 hours

• Clinically relevant ascites, edema or other fluid overload

• Uncontrolled hypertension (> 165 mmHg systolic, or > 105 mmHg diastolic)

• Hemodynamically unstable patient requiring IV nitroglycerine, or IV fluid or inotropes for blood pressure support

• Emergency (unplanned) angiography

• IV contrast procedure

• Exposure to iodinated radiocontrast within 3 days prior to study

• Prior anaphylactoid reaction to contrast

• Planned administration of N-acetylcysteine

• Planned administration of dopamine, fenoldopam or mannitol

• Current pregnancy